Shayan Jalali Bioinformatics ยท Systems Biology ยท ML

Turning biological data
into insight.

I work across transcriptomics, systems biology, and mathematical modeling โ€” building reproducible analyses and clean visualizations in R, Python, and Julia.

01 โ€” About

Who I am

I am a computational biologist working at the intersection of bioinformatics, biotechnology, and quantitative biology. I develop reproducible computational pipelines, analyze complex biological datasets, and apply statistical, machine learning, and modeling approaches to study biological systems. My interests include multi-omics data analysis, biomarker discovery, systems biology, and computational methods for advancing biomedical research and biotechnology applications.

03 โ€” Testimonials

What colleagues say

"Shayan stood out for his creativity, cross-disciplinary thinking, and valuable contributions to the model's global sensitivity analysis."

Dr. Marc Sturrock Master's Thesis Supervisor, RCSI, Ireland

"When working with student communities, you quickly notice who truly wants to learn. Shayan is a wonderful example of that group: dedicated, growth-driven, and eager to enrich any team he joins."

Dr. Iuliia Novoselova Head of Office, West German Genome Center ยท Scientific Community Manager ยท Mentor

"Shayan ranks among the top students I have supervised, combining technical skill, intellectual curiosity, and strong scientific communication."

Dr. Mohammadreza Azimi Full Professor, Dept. of Artificial Intelligence, Riga Stradins University

"Shayan combines strong scientific intuition with precise and reliable work, with an impressive ability to connect laboratory insight and computational analysis."

Dr. Justyna Malecka Mentor and Lecturer, Universitร  del Piemonte Orientale (UPO)

04 โ€” Projects

Selected work

Master Thesis project

Mathematical Modelling of Nurse Macrophage-Driven Erythropoiesis Disruption in AML

ODE-based modeling and global sensitivity analysis of AML-driven disruption of erythropoiesis, with biologically grounded hypothesis generation.

BioLionaire Code Empire book cover

BioLionaire Scientist: Volume 6 โ€“ Code Empire

Co-authored volume on computational biology, bioinformatics, genomics, AI applications, and biotechnology innovation and business strategy.

SIR epidemic simulation West Africa

SIR Epidemic Simulation (EVD in West Africa)

Julia-based Ebola simulation with the SIR model, interactive parameter tuning, realistic epidemic curves, and optional GIF animation.

Gastric cancer machine learning

Peritoneal Metastasis Prediction in Gastric Cancer

Transcriptomics + ML for biomarker panels and peritoneal metastasis prediction; validated on external GEO datasets.

Single-cell RNA-seq pipelines

Single-cell RNA-seq Pipelines

scRNA-seq preprocessing, clustering, and differential expression with Seurat/Scanpy; pathway enrichment and network analysis.

5-miRNA gastric cancer signature

5-miRNA Signature for Early Detection of Gastric Cancer

ML-validated blood-based miRNA signature for early gastric cancer detection, published as a preprint and currently under peer review.

05 โ€” Publications

Scholarly Outputs

2025โ€“26 Under Review

Remodeling of nurse macrophages and erythroblastic islands contributes to the loss of bone marrow erythropoiesis in acute myeloid leukemia

Mosteo, โ€ฆ, Sturrock, M., Jalali, S., Lo Celso, C., & Duarte, D.*

Manuscript under review (anticipated 2025โ€“2026)

2025 Preprint

From tumor pathways to blood signature: A machine-learning-validated 5-miRNA signature for the early detection of gastric cancer

Hassani, S., Momeni, M., Siahtiri, M., Massahi, S., Jalali, S., Salehi, S., & Gholaminejad, A.*

Preprints.org ยท Under review

View Preprint โ†’
2025 Preprint

Peritoneal metastasis prediction in gastric cancer: A machine learning approach

Jalali, S., Dadkhah, K., & Mirsaeid Ghazi, M.

medRxiv ยท Under review

View Preprint โ†’
2026 Published

BioLionaire Scientist: Volume 6 โ€“ Code Empire

Jabbarzadeh Kaboli, P., Jalali, S., Mohammadalizadeh Rami, S., & Salahi, S.

OncoVanguard Media, LLC

View on Amazon โ†’
2023 Published

Investigating the use of nanobodies and biotechnology methods in cancer treatment

Jalali, S.

1st International Congress of Cancer Genomics, Tehran, Iran, May 3โ€“5 2023

View Publication โ†’

06 โ€” Illustrations

Scientific Illustrations

Figures and graphical abstracts designed for research papers and presentations.

Scientific figure 1 Scientific figure 2 Scientific figure 3 Scientific figure 4 Scientific figure 5 Scientific figure 6 Scientific figure 7 Analysis of important features Performance measures plot

07 โ€” Contact

Get in touch

Open to research collaborations, PhD opportunities, and interesting projects in computational biology.